منابع مشابه
Mast Cells: Pivotal Players in Cardiovascular Diseases
The clinical outcome of cardiovascular diseases as myocardial infarction and stroke are generally caused by rupture of an atherosclerotic plaque. However, the actual cause of a plaque to rupture is not yet established. Interestingly, pathology studies have shown an increased presence of the mast cell, an important inflammatory effector cell in allergy and host defense, in (peri)vascular tissue ...
متن کاملPivotal Players and the Characterization of Influence
A player's influence relative to a mechanism and opponents' strategies is the maximum difference his action can make in the expected value of a collective outcome. A player is :-pivotal if his influence exceeds a threshold :. We provide tight bounds on the number of pivotal players and on average influence. These bounds are uniform over all mechanisms and action profiles and are achieved at mec...
متن کاملPlatelets and thromboxane receptors: pivotal players in arteriogenesis.
The reconstitution of oxygen and nutrient supply in cases of disturbed blood flow caused by tissue damage or vascular occlusion is driven by sprouting angiogenesis, arteriogenesis as an adaptation of pre-collateral vessels into collateral conduit vessels, and vasculogenesis characterized by invasion of circulating monocytic and endothelial progenitor cells. To study these mechanisms, a mouse mo...
متن کاملMultiple Myeloma Macrophages: Pivotal Players in the Tumor Microenvironment
Tumor microenvironment is essential for multiple myeloma (MM) growth, progression, and drug resistance through provision of survival signals and secretion of growth and proangiogenic factors. This paper examines the importance of macrophages within MM bone marrow (BM) microenvironment, referred to as MM-associated macrophages, as a potential niche component that supports tumor plasma cells. The...
متن کاملSteroid sulfatase: a pivotal player in estrogen synthesis and metabolism.
Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to steroids with estrogenic properties (i.e. estradiol and androstenediol) that ...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2016
ISSN: 1043-2760
DOI: 10.1016/j.tem.2016.07.003